On August 20, 1950, Chase Twichell was born in New Haven, Connecticut. She received a bachelor's degree from Trinity College in Hartford, Connecticut, in 1973 and an MFA from the University of Iowa in 1976.
Her books of poetry include Horses Where the Answers Should Have Been: New and Selected Poems (Copper Canyon Press, 2010), Dog Language (Copper Canyon Press, 2005), The Snow Watcher (Ontario Review Press, 1998), The Ghost of Eden (Ontario Review Press, 1995), Perdido (Farrar, Straus & Giroux, 1991), The Odds (University of Pittsburgh Press, 1986), and Northern Spy (University of Pittsburgh Press, 1981).
From 1976 to 1984 she worked at Pennyroyal Press, and from 1986 to 1988 she coedited the Alabama Poetry Series, published by University of Alabama Press. She also coedited The Practice of Poetry: Writing Exercises from Poets Who Teach with Robin Behn (HarperCollins, 1992).
She has won awards from the Artists Foundation, the New Jersey State Council on the Arts, and the American Academy of Arts and Letters, and fellowships from the Guggenheim Foundation and the National Endowment for the Arts.
She has taught at Princeton University, Goddard College, Warren Wilson College, the University of Alabama, and Hampshire College. In 1999 Twichell founded Ausable Press.
She lives in Keene, New York, with her husband, the novelist Russell Banks.